I first remember hearing about Alzheimer’s when I was about 10 years old. My Oma (in Holland) got it in her 70’s and my mum was telling me about it. I didn’t know my Oma very well, but I remember thinking it was so sad that if my mum went to visit her, her own mum wouldn’t even recognize her.
That was 30 years ago, and despite over 50 billion dollars being spent on research and drug development, it’s getting worse. The number of people with Alzheimer’s is expected to double every 20 years, and if it continues on this trajectory it is expected the bankrupt the USA economy (and likely other countries) in the next few decades.
However there has been one researcher, Dr Dale Bredesen, who has been investigating the root causes of Alzheimer’s and is getting some amazing results. He has found that toxic exposure is a contributing factor in many cases of Alzheimer’s. One of the most common toxins he finds in his patients is mould toxins (aka mycotoxins).
He has found there are 4 main drivers of Alzheimers
1. Inflammation: leaky gut, chronic infections, chronic sinusitis, a poor oral microbiome with poor dentition etc
2. Energy. Not enough energy to support the neural network. This relates to cerebral blood flow, oxygenation, mitochondrial function and ketones.
3. Toxicity " anything that creates toxicity, and this can be inorganics, organics or biotoxins. So of course, there has been a lot of press on the relationship between air pollution and cognitive decline, but also heavy metals like mercury may contribute. It can also be organics, things like toluene or benzene. Or it can be biotoxins, such as trichothecenes, ochratoxin A or gliotoxin. These all essentially create drag, increased requirements on the system" -Dale Bredesen (ref below)
4. Trophic support. Lack of nerve growth factor, BDNF. Imbalance in hormones like estradiol, testosterone, progresterone, thyroid hormones. Nutrients like Vitamin D, vitamin B12 etc
While mycotoxins fit into category 3, they can have an impact on the other categories. Ie. can create leaky gut, more succeptible to infections, reduce energy metabolism and mitochondrial function, create hormone imbalance and nutrient deficiencies.
When this mould toxicity is assessed and addressed, he is finding that many of these cases of Alzheimer’s are reversible. He has termed this Type 3 Alzheimer’s, or Inhalational Alzheimer’s.
Inhalational Alzheimer’s has some specific signs and symptoms, which make it different to the classical Alzheimer’s presentation.
These include
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Symptoms begin before age 65. For women this is often around perimenopause or menopause
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Often ApoE4 negative and no family history
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Depression precedes or accompanies the cognitive decline
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Headache is an early symptom
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Executive function deficits (planning, problem solving, organizing etc)
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Problems with number calculations
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Trouble speaking or loss of speech
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Problems with learned programs ie. dressing
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Starts or worsened by period of great stress (ie. lost job, divorce) with sleep loss
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Exposure to mould toxins, heavy metals or other toxins
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Low triglycerides, and low triglyceride-cholesterol ratio on a blood test
If you are concerned about cognitive decline, or Alzheimer’s, in yourself, a loved one or friend- it’s worth considering whether indoor mould is a factor. Over 50% of New Zealand homes have some level of water damage and mould, and it can often be overlooked.
Starting with the mould questionnaire and the vcs test (both free) is a place to start. There is more advanced testing such as the Urine Mycotoxin Test which can identify specific mycotoxins in the body. Check out our free guide to testing your body here
Testing your home is also important, as this will tell you if you are being exposed to unhealthy levels of mould and mycotoxins.
References
Cognitive impariment associated with toxigenic fungal exposure: a replication and extension of previous findings https://pubmed.ncbi.nlm.nih.gov/15477176/
The Diagnosis of Cognitive Impairment Associated with Exposure to Mold https://www.sciencedirect.com/science/article/abs/pii/S0065216404550141?via%3Dihub
Conversation with Dale Bredesen https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8594968/